1w3z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:53, 6 November 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1w3z.png|left|200px]]
 
-
{{STRUCTURE_1w3z| PDB=1w3z | SCENE= }}
+
==SeMet derivative of BbCRASP-1 from Borrelia Burgdorferi==
 +
<StructureSection load='1w3z' size='340' side='right'caption='[[1w3z]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1w3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_ZS7 Borreliella burgdorferi ZS7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W3Z FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3z OCA], [https://pdbe.org/1w3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w3z RCSB], [https://www.ebi.ac.uk/pdbsum/1w3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w3z ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/O50957_BORBU O50957_BORBU]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/1w3z_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w3z ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.
-
===SEMET DERIVATIVE OF BBCRASP-1 FROM BORRELIA BURGDORFERI===
+
A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.,Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564<ref>PMID:15711564</ref>
-
{{ABSTRACT_PUBMED_15711564}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1w3z" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[1w3z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3Z OCA].
+
*[[Complement Regulator-Acquiring Surface Protein|Complement Regulator-Acquiring Surface Protein]]
-
 
+
*[[Complement regulator-acquiring surface protein|Complement regulator-acquiring surface protein]]
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:015711564</ref><ref group="xtra">PMID:015103142</ref><references group="xtra"/>
+
<references/>
-
[[Category: Borrelia burgdorferi]]
+
__TOC__
-
[[Category: Brade, V.]]
+
</StructureSection>
-
[[Category: Cordes, F S.]]
+
[[Category: Borreliella burgdorferi ZS7]]
-
[[Category: Goodstadt, L.]]
+
[[Category: Large Structures]]
-
[[Category: Kirschfink, M.]]
+
[[Category: Brade V]]
-
[[Category: Kraiczy, P.]]
+
[[Category: Cordes FS]]
-
[[Category: Lea, S M.]]
+
[[Category: Goodstadt L]]
-
[[Category: Ponting, C.]]
+
[[Category: Kirschfink M]]
-
[[Category: Roversi, P.]]
+
[[Category: Kraiczy P]]
-
[[Category: Simon, M M.]]
+
[[Category: Lea SM]]
-
[[Category: Skerka, C.]]
+
[[Category: Ponting C]]
-
[[Category: Wallich, R.]]
+
[[Category: Roversi P]]
-
[[Category: Zipfel, P.]]
+
[[Category: Simon MM]]
-
[[Category: Complement regulator]]
+
[[Category: Skerka C]]
-
[[Category: Complement regulator acquiring surface protein]]
+
[[Category: Wallich R]]
-
[[Category: Factor h binding]]
+
[[Category: Zipfel P]]
-
[[Category: Lyme borreliosis]]
+
-
[[Category: Selenomethionine]]
+
-
[[Category: Tick]]
+

Current revision

SeMet derivative of BbCRASP-1 from Borrelia Burgdorferi

PDB ID 1w3z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1w3z"
Personal tools