2a8f

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[[Image:2a8f.png|left|200px]]
 
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{{STRUCTURE_2a8f| PDB=2a8f | SCENE= }}
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==beta-cinnamomin after sterol removal==
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<StructureSection load='2a8f' size='340' side='right'caption='[[2a8f]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2a8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Phytophthora_cinnamomi Phytophthora cinnamomi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A8F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a8f OCA], [https://pdbe.org/2a8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a8f RCSB], [https://www.ebi.ac.uk/pdbsum/2a8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a8f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELIB_PHYCI ELIB_PHYCI] Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families. Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins. Might interact with the lipidic molecules of the plasma membrane. Elicitins are able to load, carry, and transfer sterols between membranes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/2a8f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a8f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the elicitin beta-cinnamomin (beta-CIN) was determined in complex with ergosterol at 1.1 A resolution. beta-CIN/ergosterol complex crystallized in the monoclinic space group P2(1), with unit cell parameters of a = 31.0, b = 62.8, c = 50.0 A and beta = 93.4 degrees and two molecules in the asymmetric unit. Ligand extraction with chloroform followed by crystallographic analysis yielded a 1.35 A structure of beta-CIN (P4(3)2(1)2 space group) where the characteristic elicitin fold was kept. After incubation with cholesterol, a new complex structure was obtained, showing that the protein retains, after the extraction procedure, its ability to complex sterols. The necrotic effect of beta-CIN on tobacco was also shown to remain unchanged. Theoretical docking studies of the triterpene lupeol to beta-CIN provided an explanation for the apparent inability of beta-CIN to bind this ligand, as observed experimentally.
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===beta-cinnamomin after sterol removal===
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Crystal structures of the free and sterol-bound forms of beta-cinnamomin.,Rodrigues ML, Archer M, Martel P, Miranda S, Thomaz M, Enguita FJ, Baptista RP, Pinho e Melo E, Sousa N, Cravador A, Carrondo MA Biochim Biophys Acta. 2006 Jan;1764(1):110-21. Epub 2005 Oct 6. PMID:16249127<ref>PMID:16249127</ref>
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{{ABSTRACT_PUBMED_16249127}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2a8f" style="background-color:#fffaf0;"></div>
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[[2a8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phytophthora_cinnamomi Phytophthora cinnamomi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A8F OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016249127</ref><ref group="xtra">PMID:012136143</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Phytophthora cinnamomi]]
[[Category: Phytophthora cinnamomi]]
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[[Category: Archer, M.]]
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[[Category: Archer M]]
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[[Category: Baptista, R P.]]
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[[Category: Baptista RP]]
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[[Category: Carrondo, M A.]]
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[[Category: Carrondo MA]]
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[[Category: Cravador, A.]]
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[[Category: Cravador A]]
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[[Category: Enguita, F J.]]
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[[Category: Enguita FJ]]
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[[Category: Martel, P.]]
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[[Category: Martel P]]
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[[Category: Melo, E P.]]
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[[Category: Melo EP]]
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[[Category: Miranda, S.]]
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[[Category: Miranda S]]
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[[Category: Rodrigues, M L.]]
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[[Category: Rodrigues ML]]
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[[Category: Sousa, N.]]
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[[Category: Sousa N]]
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[[Category: Thomaz, M.]]
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[[Category: Thomaz M]]
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[[Category: Elicitin]]
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[[Category: Phytopathogen]]
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[[Category: Phytophthora]]
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[[Category: Sterol carrier protein]]
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[[Category: Toxin]]
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Current revision

beta-cinnamomin after sterol removal

PDB ID 2a8f

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