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1xj9

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[[Image:1xj9.png|left|200px]]
 
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{{STRUCTURE_1xj9| PDB=1xj9 | SCENE= }}
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==Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network==
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<StructureSection load='1xj9' size='340' side='right'caption='[[1xj9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xj9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XJ9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-ADENINE'>APN</scene>, <scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xj9 OCA], [https://pdbe.org/1xj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xj9 RCSB], [https://www.ebi.ac.uk/pdbsum/1xj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xj9 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray structure of a partly self-complementary peptide nucleic acid (PNA) decamer (H-GTAGATCACT-l-Lys-NH(2)) to 2.60 A resolution is reported. The structure is mainly controlled by the canonical Watson-Crick base pairs formed by the self-complementary stretch of four bases in the middle of the decamer (G(4)A(5)T(6)C(7)). One right- and one left-handed Watson-Crick duplex are formed. The two PNA units C(9)T(10) change helical handedness, so that each PNA strand contains both a right- and a left-handed section. The changed handedness in C(9)T(10) allows formation of Hoogsteen hydrogen bonding between C(9)T(10) and G(4)A(5) of a PNA strand in an adjacent Watson-Crick double helix of the same handedness. Thereby, a PNA-PNA-PNA triplex is formed. The PNA unit A(3) forms a noncanonical base pair with A(8) in a symmetry-related strand of opposite handedness; the base pair is of the A-A reverse Hoogsteen type. The structural diversity of this PNA demonstrates how the PNA backbone is able to adapt to structures governed by the stacking and hydrogen-bonding interactions between the nucleobases. The crystal structure further shows how PNA oligomers containing limited sequence complementarity may form complex hydrogen-bonding networks.
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===Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network===
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Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network.,Petersson B, Nielsen BB, Rasmussen H, Larsen IK, Gajhede M, Nielsen PE, Kastrup JS J Am Chem Soc. 2005 Feb 9;127(5):1424-30. PMID:15686374<ref>PMID:15686374</ref>
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{{ABSTRACT_PUBMED_15686374}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1xj9" style="background-color:#fffaf0;"></div>
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[[1xj9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XJ9 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015686374</ref><ref group="xtra">PMID:009033585</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Gajhede, M.]]
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[[Category: Large Structures]]
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[[Category: Kastrup, J S.]]
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[[Category: Gajhede M]]
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[[Category: Larsen, I K.]]
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[[Category: Kastrup JS]]
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[[Category: Nielsen, B B.]]
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[[Category: Larsen IK]]
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[[Category: Nielsen, P E.]]
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[[Category: Nielsen BB]]
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[[Category: Petersson, B.]]
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[[Category: Nielsen PE]]
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[[Category: Rasmussen, H.]]
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[[Category: Petersson B]]
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[[Category: Duplex-triplex complex]]
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[[Category: Rasmussen H]]
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[[Category: Left-handed]]
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[[Category: Partly self-complementary]]
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[[Category: Peptide nucleic acid]]
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[[Category: Pna]]
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[[Category: Right-handed]]
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Current revision

Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network

PDB ID 1xj9

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