2c45

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[[Image:2c45.png|left|200px]]
 
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{{STRUCTURE_2c45| PDB=2c45 | SCENE= }}
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==NATIVE PRECURSOR OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE==
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<StructureSection load='2c45' size='340' side='right'caption='[[2c45]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2c45]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C45 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c45 OCA], [https://pdbe.org/2c45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c45 RCSB], [https://www.ebi.ac.uk/pdbsum/2c45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c45 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAND_MYCTU PAND_MYCTU] Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c45_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c45 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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L-aspartate-alpha-decarboxylase (ADC) is a critical regulatory enzyme in the pantothenate biosynthetic pathway and belongs to a small class of self-cleaving and pyruvoyl-dependent amino acid decarboxylases. The expression level of ADC in Mycobacterium tuberculosis (Mtb) was confirmed by cDNA analysis, immunoblotting with an anti-ADC polyclonal antibody using whole cell lysate and immunoelectron microscopy. The recombinant ADC proenzyme from Mycobacterium tuberculosis (MtbADC) was overexpressed in E. coli and the protein structure was determined at 2.99 A resolution. The proteins fold into the double-psi beta-barrel structure. The subunits of the two tetramers (there are eight ADC molecules in the asymmetric unit) form pseudo fourfold rotational symmetry, similar to the E. coli ADC proenzyme structure. As pantothenate is synthesized in microorganisms, plants, and fungi but not in animals, structure elucidation of Mtb ADC is of substantial interest for structure-based drug development.
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===NATIVE PRECURSOR OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE===
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Crystal structure of uncleaved L-aspartate-alpha-decarboxylase from Mycobacterium tuberculosis.,Gopalan G, Chopra S, Ranganathan A, Swaminathan K Proteins. 2006 Dec 1;65(4):796-802. PMID:17001646<ref>PMID:17001646</ref>
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{{ABSTRACT_PUBMED_17001646}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2c45" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2c45]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C45 OCA].
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*[[Aspartate decarboxylase 3D structures|Aspartate decarboxylase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017001646</ref><ref group="xtra">PMID:009546220</ref><ref group="xtra">PMID:014633979</ref><ref group="xtra">PMID:015184017</ref><references group="xtra"/>
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__TOC__
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[[Category: Aspartate 1-decarboxylase]]
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</StructureSection>
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[[Category: Chopra, S.]]
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[[Category: Large Structures]]
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[[Category: Gopalan, G.]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Ranganathan, A.]]
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[[Category: Chopra S]]
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[[Category: Swaminathan, K.]]
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[[Category: Gopalan G]]
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[[Category: Carboxylase]]
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[[Category: Ranganathan A]]
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[[Category: Decarboxylase]]
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[[Category: Swaminathan K]]
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[[Category: Double-psi beta barrel]]
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[[Category: Lyase]]
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[[Category: Pantothenate biosynthesis]]
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[[Category: Pyruvate]]
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[[Category: Zymogen]]
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Current revision

NATIVE PRECURSOR OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE

PDB ID 2c45

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