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2m2e

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'''Unreleased structure'''
 
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The entry 2m2e is ON HOLD until Feb 12 2014
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==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==
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<StructureSection load='2m2e' size='340' side='right'caption='[[2m2e]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [https://pdbe.org/2m2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [https://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>
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Authors: Lemak, A., Yee, A., Houliston, S., Garcia, M., Ong, M., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
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==See Also==
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*[[DnaJ homolog 3D structures|DnaJ homolog 3D structures]]
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Description: Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a (CASD-NMR Target)
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Garcia M]]
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[[Category: Houliston S]]
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[[Category: Lemak A]]
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[[Category: Montelione GT]]
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[[Category: Ong M]]
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[[Category: Yee A]]

Current revision

Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a

PDB ID 2m2e

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