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Disintegrin

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[[Image:1z1x.png|left|200px|thumb|Crystal Structure of Disintegrin [[1z1x]]]]
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<StructureSection load='' size='350' side='right' scene='Disintegrin/Cv/1' caption='Disintegrin, [[1z1x]]'>
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{{STRUCTURE_1z1x| PDB=1z1x | SIZE=400| SCENE=Disintegrin/Cv/1 |right|CAPTION=Disintegrin [[1z1x]] }}
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== Function ==
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[[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref> Over 100 disintegrins have been studied.
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== Relevance ==
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Disintegrins, which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>.
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</StructureSection>
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[[Disintegrin|Disintegrins]] are a family of toxins from viper venoms which inhibit platelet aggregation and cell adhesion. The images at the left and at the right correspond to one representative Disintegrin, ''i.e.'' the crystal structure of Disintegrin from ''Echis carinatus'' ([[1z1x]]).
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{{TOC limit|limit=2}}
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== 3D Structures of Disintegrin ==
== 3D Structures of Disintegrin ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[2w9o]], [[2w9u]], [[2w9v]], [[2w9w]] – jerdostatin residues 68-110 – ''Trimeresurus jerdonii'' – NMR<br />
[[2w9o]], [[2w9u]], [[2w9v]], [[2w9w]] – jerdostatin residues 68-110 – ''Trimeresurus jerdonii'' – NMR<br />
[[1j2l]] – trimestatin - ''Trimeresurus flavovidrius''<br />
[[1j2l]] – trimestatin - ''Trimeresurus flavovidrius''<br />
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[[2pjf]], [[1q7i]], [[1q7j]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br />
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[[2pjf]], [[1q7i]], [[1q7j]], [[1n4y]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br />
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[[2pjg]], [[2pji]] - Cr rhodostoxin (mutant) – NMR<br />
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[[2pjg]], [[2pji]], [[2ljv]] - Cr rhodostoxin (mutant) 1-68 – NMR<br />
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[[3uci]], [[4m4c]], [[4r5r]], [[4r5u]], [[4rqg]] - Cr rhodostoxin (mutant) 408-475<br />
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[[2m75]], [[2m7f]], [[2m7h]] - Cr rhodostoxin (mutant) 408-475 – NMR<br />
[[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br />
[[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br />
[[1rmr]] – Ec schistatin<br />
[[1rmr]] – Ec schistatin<br />
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[[6lsq]] – Ec echistatin<br />
[[1ro3]], [[2ech]] – Ec echistatin - NMR<br />
[[1ro3]], [[2ech]] – Ec echistatin - NMR<br />
[[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br />
[[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br />
[[1mpz]] – obtustatin – ''Macrovipera obtusa'' - NMR<br />
[[1mpz]] – obtustatin – ''Macrovipera obtusa'' - NMR<br />
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[[1dem]] – dendrotoxin I – black mamba<br />
 
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[[1den]] - dendrotoxin I - NMR<br />
 
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[[1dtk]] - dendrotoxin K- NMR<br />
 
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[[1dtx]] – α-dendrotoxin - Eastern green mamba<br />
 
[[3c05]] – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead<br />
[[3c05]] – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead<br />
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[[3dsl]] – bothropasin - Jararaca
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[[3dsl]] – bothropasin - Jararaca<br />
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[[2dw0]], [[2dw1]], [[2dw2]] – catrocollastatin – rattlesnake<br />
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[[2mop]], [[2mp5]] – bitistatin – African puff adder - NMR<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Disintegrin, 1z1x

Drag the structure with the mouse to rotate

3D Structures of Disintegrin

Updated on 30-January-2023

2w9o, 2w9u, 2w9v, 2w9w – jerdostatin residues 68-110 – Trimeresurus jerdonii – NMR
1j2l – trimestatin - Trimeresurus flavovidrius
2pjf, 1q7i, 1q7j, 1n4y – Cr rhodostoxin residues 1-68 – Calloselasma rhodostoma – NMR
2pjg, 2pji, 2ljv - Cr rhodostoxin (mutant) 1-68 – NMR
3uci, 4m4c, 4r5r, 4r5u, 4rqg - Cr rhodostoxin (mutant) 408-475
2m75, 2m7f, 2m7h - Cr rhodostoxin (mutant) 408-475 – NMR
1z1x, 1tej – Ec disintegrin – Echis carinatus
1rmr – Ec schistatin
6lsq – Ec echistatin
1ro3, 2ech – Ec echistatin - NMR
1l3x – salmosin – Gloydius brevicaudus – NMR
1mpz – obtustatin – Macrovipera obtusa - NMR
3c05 – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead
3dsl – bothropasin - Jararaca
2dw0, 2dw1, 2dw2 – catrocollastatin – rattlesnake
2mop, 2mp5 – bitistatin – African puff adder - NMR


References

  1. ↑ McLane MA, Sanchez EE, Wong A, Paquette-Straub C, Perez JC. Disintegrins. Curr Drug Targets Cardiovasc Haematol Disord. 2004 Dec;4(4):327-55. PMID:15578957
  2. ↑ McLane MA, Joerger T, Mahmoud A. Disintegrins in health and disease. Front Biosci. 2008 May 1;13:6617-37. PMID:18508683

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