3zkr

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(New page: '''Unreleased structure''' The entry 3zkr is ON HOLD until Paper Publication Authors: Spurny, R., Billen, B., Howard, R.J., Brams, M., Debaveye, S., Price, K.L., Weston, D.A., Strelkov,...)
Current revision (10:40, 9 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3zkr is ON HOLD until Paper Publication
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==X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoform==
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<StructureSection load='3zkr' size='340' side='right'caption='[[3zkr]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zkr]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_chrysanthemi Dickeya chrysanthemi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZKR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.649&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MBR:TRIBROMOMETHANE'>MBR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zkr OCA], [https://pdbe.org/3zkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zkr RCSB], [https://www.ebi.ac.uk/pdbsum/3zkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zkr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELIC_DICCH ELIC_DICCH]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine, glycine, gamma-aminobutyric acid GABAA/C receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are receptors that contain multiple allosteric binding sites for a variety of therapeutics, including general anesthetics. Here, we report the x-ray crystal structure of the Erwinia chrysanthemi ligand-gated ion channel (ELIC) in complex with a derivative of chloroform, which reveals important features of anesthetic recognition, involving multiple binding at three different sites. One site is located in the channel pore and equates with a noncompetitive inhibitor site found in many pLGICs. A second transmembrane site is novel and is located in the lower part of the transmembrane domain, at an interface formed between adjacent subunits. A third site is also novel and is located in the extracellular domain in a hydrophobic pocket between the beta7-beta10 strands. Together, these results extend our understanding of pLGIC modulation and reveal several specific binding interactions that may contribute to modulator recognition, further substantiating a multisite model of allosteric modulation in this family of ion channels.
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Authors: Spurny, R., Billen, B., Howard, R.J., Brams, M., Debaveye, S., Price, K.L., Weston, D.A., Strelkov, S., Tytgat, J., Bertrand, S., Bertrand, D., Lummis, S.C.R., Ulens, C.
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Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC).,Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C J Biol Chem. 2013 Mar 22;288(12):8355-64. doi: 10.1074/jbc.M112.424507. Epub 2013, Jan 30. PMID:23364792<ref>PMID:23364792</ref>
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Description: X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoform
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zkr" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Dickeya chrysanthemi]]
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[[Category: Large Structures]]
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[[Category: Bertrand D]]
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[[Category: Bertrand S]]
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[[Category: Billen B]]
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[[Category: Brams M]]
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[[Category: Debaveye S]]
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[[Category: Howard RJ]]
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[[Category: Lummis SCR]]
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[[Category: Price KL]]
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[[Category: Spurny R]]
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[[Category: Strelkov SV]]
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[[Category: Tytgat J]]
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[[Category: Ulens C]]
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[[Category: Weston DA]]

Current revision

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoform

PDB ID 3zkr

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