Disintegrin
From Proteopedia
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| - | + | <StructureSection load='' size='350' side='right' scene='Disintegrin/Cv/1' caption='Disintegrin, [[1z1x]]'> | |
| - | + | == Function == | |
| + | [[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref> Over 100 disintegrins have been studied. | ||
| + | == Relevance == | ||
| - | + | Disintegrins, which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>. | |
| - | + | </StructureSection> | |
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== 3D Structures of Disintegrin == | == 3D Structures of Disintegrin == | ||
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| - | + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |
[[2w9o]], [[2w9u]], [[2w9v]], [[2w9w]] – jerdostatin residues 68-110 – ''Trimeresurus jerdonii'' – NMR<br /> | [[2w9o]], [[2w9u]], [[2w9v]], [[2w9w]] – jerdostatin residues 68-110 – ''Trimeresurus jerdonii'' – NMR<br /> | ||
[[1j2l]] – trimestatin - ''Trimeresurus flavovidrius''<br /> | [[1j2l]] – trimestatin - ''Trimeresurus flavovidrius''<br /> | ||
| - | [[2pjf]], [[1q7i]], [[1q7j]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br /> | + | [[2pjf]], [[1q7i]], [[1q7j]], [[1n4y]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br /> |
| - | [[2pjg]], [[2pji]], [[ | + | [[2pjg]], [[2pji]], [[2ljv]] - Cr rhodostoxin (mutant) 1-68 – NMR<br /> |
| - | [[3uci]] - Cr rhodostoxin (mutant)<br /> | + | [[3uci]], [[4m4c]], [[4r5r]], [[4r5u]], [[4rqg]] - Cr rhodostoxin (mutant) 408-475<br /> |
| + | [[2m75]], [[2m7f]], [[2m7h]] - Cr rhodostoxin (mutant) 408-475 – NMR<br /> | ||
[[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br /> | [[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br /> | ||
[[1rmr]] – Ec schistatin<br /> | [[1rmr]] – Ec schistatin<br /> | ||
| + | [[6lsq]] – Ec echistatin<br /> | ||
[[1ro3]], [[2ech]] – Ec echistatin - NMR<br /> | [[1ro3]], [[2ech]] – Ec echistatin - NMR<br /> | ||
[[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br /> | [[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br /> | ||
[[1mpz]] – obtustatin – ''Macrovipera obtusa'' - NMR<br /> | [[1mpz]] – obtustatin – ''Macrovipera obtusa'' - NMR<br /> | ||
| - | [[1dem]] – dendrotoxin I – black mamba<br /> | ||
| - | [[1den]] - dendrotoxin I - NMR<br /> | ||
| - | [[1dtk]] - dendrotoxin K- NMR<br /> | ||
| - | [[1dtx]] – α-dendrotoxin - Eastern green mamba<br /> | ||
[[3c05]] – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead<br /> | [[3c05]] – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead<br /> | ||
| - | [[3dsl]] – bothropasin - Jararaca | + | [[3dsl]] – bothropasin - Jararaca<br /> |
| + | [[2dw0]], [[2dw1]], [[2dw2]] – catrocollastatin – rattlesnake<br /> | ||
| + | [[2mop]], [[2mp5]] – bitistatin – African puff adder - NMR<br /> | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Disintegrin
Updated on 30-January-2023
2w9o, 2w9u, 2w9v, 2w9w – jerdostatin residues 68-110 – Trimeresurus jerdonii – NMR
1j2l – trimestatin - Trimeresurus flavovidrius
2pjf, 1q7i, 1q7j, 1n4y – Cr rhodostoxin residues 1-68 – Calloselasma rhodostoma – NMR
2pjg, 2pji, 2ljv - Cr rhodostoxin (mutant) 1-68 – NMR
3uci, 4m4c, 4r5r, 4r5u, 4rqg - Cr rhodostoxin (mutant) 408-475
2m75, 2m7f, 2m7h - Cr rhodostoxin (mutant) 408-475 – NMR
1z1x, 1tej – Ec disintegrin – Echis carinatus
1rmr – Ec schistatin
6lsq – Ec echistatin
1ro3, 2ech – Ec echistatin - NMR
1l3x – salmosin – Gloydius brevicaudus – NMR
1mpz – obtustatin – Macrovipera obtusa - NMR
3c05 – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead
3dsl – bothropasin - Jararaca
2dw0, 2dw1, 2dw2 – catrocollastatin – rattlesnake
2mop, 2mp5 – bitistatin – African puff adder - NMR
References
- ↑ McLane MA, Sanchez EE, Wong A, Paquette-Straub C, Perez JC. Disintegrins. Curr Drug Targets Cardiovasc Haematol Disord. 2004 Dec;4(4):327-55. PMID:15578957
- ↑ McLane MA, Joerger T, Mahmoud A. Disintegrins in health and disease. Front Biosci. 2008 May 1;13:6617-37. PMID:18508683
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