4f0v
From Proteopedia
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| - | [[Image:4f0v.png|left|200px]] | ||
| - | + | ==Crystal structure of type effector Tse1 from Pseudomonas aeruginousa== | |
| + | <StructureSection load='4f0v' size='340' side='right'caption='[[4f0v]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4f0v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F0V FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f0v OCA], [https://pdbe.org/4f0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f0v RCSB], [https://www.ebi.ac.uk/pdbsum/4f0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f0v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TSE1_PSEAE TSE1_PSEAE] Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria (PubMed:21776080, PubMed:22931054, PubMed:22813741, PubMed:22700987). To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin (PubMed:21776080, PubMed:22931054, PubMed:22700987).<ref>PMID:21776080</ref> <ref>PMID:22700987</ref> <ref>PMID:22813741</ref> <ref>PMID:22931054</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The type VI secretion systems (T6SS) have emerging roles in interspecies competition. In order to have an advantage in defense against other organisms, this system in Pseudomonas aeruginosa delivers a peptidoglycan amidase (Tse1) to the periplasmic space of a competitor. An immune protein (Tsi1) is also produced by the bacterium to protect itself from damage caused by Tse1. Tsi1 directly interacts with Tse1. We report that the crystal structure of Tse1 displays a common CHAP protein fold. Strikingly, our structures showed that the third residue in the catalytic triad may be novel as this residue type has not been observed previously. | ||
| - | + | Crystal structure of type VI effector Tse1 from Pseudomonas aeruginosa.,Zhang H, Gao ZQ, Su XD, Dong YH FEBS Lett. 2012 Sep 21;586(19):3193-9. doi: 10.1016/j.febslet.2012.06.036. Epub, 2012 Jun 29. PMID:22750141<ref>PMID:22750141</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | <div class="pdbe-citations 4f0v" style="background-color:#fffaf0;"></div> |
| - | + | == References == | |
| - | [[Category: Pseudomonas aeruginosa | + | <references/> |
| - | [[Category: Dong | + | __TOC__ |
| - | [[Category: Gao | + | </StructureSection> |
| - | [[Category: Zhang | + | [[Category: Large Structures]] |
| - | + | [[Category: Pseudomonas aeruginosa PAO1]] | |
| - | + | [[Category: Dong YH]] | |
| - | + | [[Category: Gao ZQ]] | |
| + | [[Category: Zhang H]] | ||
Current revision
Crystal structure of type effector Tse1 from Pseudomonas aeruginousa
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