4ejr
From Proteopedia
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| - | [[Image:4ejr.jpg|left|200px]] | ||
| - | + | ==Crystal structure of major capsid protein S domain from rabbit hemorrhagic disease virus== | |
| + | <StructureSection load='4ejr' size='340' side='right'caption='[[4ejr]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ejr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabbit_hemorrhagic_disease_virus Rabbit hemorrhagic disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EJR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ejr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ejr OCA], [https://pdbe.org/4ejr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ejr RCSB], [https://www.ebi.ac.uk/pdbsum/4ejr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ejr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q3HNQ2_RHDV Q3HNQ2_RHDV] 3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved.[ARBA:ARBA00003176] Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.[ARBA:ARBA00024666] NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.[ARBA:ARBA00025124] Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.[ARBA:ARBA00025359] | ||
| - | == | + | ==See Also== |
| - | + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | [[Category: Large Structures]] |
[[Category: Rabbit hemorrhagic disease virus]] | [[Category: Rabbit hemorrhagic disease virus]] | ||
| - | [[Category: Ma | + | [[Category: Ma J]] |
| - | [[Category: Sun | + | [[Category: Sun F]] |
| - | [[Category: Wang | + | [[Category: Wang X]] |
| - | [[Category: Xu | + | [[Category: Xu F]] |
| - | [[Category: Zhang | + | [[Category: Zhang K]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of major capsid protein S domain from rabbit hemorrhagic disease virus
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