2lm0
From Proteopedia
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| - | [[Image:2lm0.png|left|200px]] | ||
| - | + | ==Solution structure of the AF4-AF9 complex== | |
| - | + | <StructureSection load='2lm0' size='340' side='right'caption='[[2lm0]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2lm0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LM0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lm0 OCA], [https://pdbe.org/2lm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lm0 RCSB], [https://www.ebi.ac.uk/pdbsum/2lm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lm0 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2lm0]] is a 1 chain structure with sequence from [ | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/AFF1_HUMAN AFF1_HUMAN] Precursor B-cell acute lymphoblastic leukemia. A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AFF1_HUMAN AFF1_HUMAN] [https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bushweller | + | [[Category: Large Structures]] |
| - | [[Category: Cierpicki | + | [[Category: Bushweller JH]] |
| - | [[Category: Johnson | + | [[Category: Cierpicki T]] |
| - | [[Category: Kuntimaddi | + | [[Category: Johnson SA]] |
| - | [[Category: Leach | + | [[Category: Kuntimaddi A]] |
| - | [[Category: Schmidt | + | [[Category: Leach BI]] |
| - | + | [[Category: Schmidt CR]] | |
| - | + | ||
Current revision
Solution structure of the AF4-AF9 complex
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