2rj2

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[[Image:2rj2.png|left|200px]]
 
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{{STRUCTURE_2rj2| PDB=2rj2 | SCENE= }}
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==Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution==
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<StructureSection load='2rj2' size='340' side='right'caption='[[2rj2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rj2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJ2 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14990996}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rj2 OCA], [https://pdbe.org/2rj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rj2 RCSB], [https://www.ebi.ac.uk/pdbsum/2rj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rj2 ProSAT]</span></td></tr>
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[[2rj2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ2 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/FBX2_MOUSE FBX2_MOUSE] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.<ref>PMID:12140560</ref> <ref>PMID:15723043</ref> <ref>PMID:17720138</ref> <ref>PMID:17215248</ref> <ref>PMID:14990996</ref>
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<ref group="xtra">PMID:014990996</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rj2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rj2 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Mizushima T]]
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[[Category: Mizushima, T.]]
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[[Category: Tanaka K]]
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[[Category: Tanaka, K.]]
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[[Category: Vaijayanthimala S]]
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[[Category: Vaijayanthimala, S.]]
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[[Category: Velmurugan D]]
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[[Category: Velmurugan, D.]]
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[[Category: Yamane T]]
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[[Category: Yamane, T.]]
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[[Category: Yoshida Y]]
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[[Category: Yoshida, Y.]]
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[[Category: Lectin]]
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[[Category: Ligase]]
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[[Category: Scf]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin ligase]]
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[[Category: Ubl conjugation pathway]]
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Current revision

Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution

PDB ID 2rj2

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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