2i3h

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[[Image:2i3h.png|left|200px]]
 
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{{STRUCTURE_2i3h| PDB=2i3h | SCENE= }}
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==Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)==
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<StructureSection load='2i3h' size='340' side='right'caption='[[2i3h]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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===Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2i3h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I3H FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17168540}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i3h OCA], [https://pdbe.org/2i3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i3h RCSB], [https://www.ebi.ac.uk/pdbsum/2i3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i3h ProSAT]</span></td></tr>
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[[2i3h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I3H OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/BIRC7_HUMAN BIRC7_HUMAN] Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.<ref>PMID:11084335</ref> <ref>PMID:16729033</ref> <ref>PMID:17294084</ref> <ref>PMID:18034418</ref>
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<ref group="xtra">PMID:017168540</ref><ref group="xtra">PMID:015485396</ref><ref group="xtra">PMID:012846571</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i3h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i3h ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fairbrother, W J.]]
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[[Category: Large Structures]]
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[[Category: Franklin, M C.]]
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[[Category: Fairbrother WJ]]
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[[Category: Apoptosis inhibition]]
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[[Category: Franklin MC]]
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[[Category: Drug design]]
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[[Category: Inhibitor-apoptosis complex]]
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[[Category: Peptide complex]]
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[[Category: Peptidomimetic]]
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[[Category: Small molecule]]
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[[Category: Zinc binding]]
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Current revision

Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)

PDB ID 2i3h

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