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2w1b
From Proteopedia
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| - | [[Image:2w1b.png|left|200px]] | ||
| - | + | ==The structure of the efflux pump AcrB in complex with bile acid== | |
| + | <StructureSection load='2w1b' size='340' side='right'caption='[[2w1b]], [[Resolution|resolution]] 3.85Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2w1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W1B FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.85Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1b OCA], [https://pdbe.org/2w1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w1b RCSB], [https://www.ebi.ac.uk/pdbsum/2w1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w1b ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex. | ||
| - | + | The structure of the efflux pump AcrB in complex with bile acid.,Drew D, Klepsch MM, Newstead S, Flaig R, De Gier JW, Iwata S, Beis K Mol Membr Biol. 2008 Dec;25(8):677-82. PMID:19023693<ref>PMID:19023693</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2w1b" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
| - | [[Category: Escherichia coli | + | [[Category: Escherichia coli K-12]] |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | [[Category: Beis K]] |
| - | [[Category: | + | [[Category: De Gier JW]] |
| - | [[Category: Gier | + | [[Category: Drew D]] |
| - | [[Category: | + | [[Category: Flaig R]] |
| - | [[Category: | + | [[Category: Iwata S]] |
| - | [[Category: | + | [[Category: Klepsch MM]] |
| - | [[Category: | + | [[Category: Newstead S]] |
| - | [[Category: | + | |
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Current revision
The structure of the efflux pump AcrB in complex with bile acid
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Categories: Escherichia coli K-12 | Large Structures | Beis K | De Gier JW | Drew D | Flaig R | Iwata S | Klepsch MM | Newstead S
