2vrs

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[[Image:2vrs.png|left|200px]]
 
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{{STRUCTURE_2vrs| PDB=2vrs | SCENE= }}
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==Structure of avian reovirus sigmaC117-326, C2 crystal form==
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<StructureSection load='2vrs' size='340' side='right'caption='[[2vrs]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vrs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_orthoreovirus Avian orthoreovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VRS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrs OCA], [https://pdbe.org/2vrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vrs RCSB], [https://www.ebi.ac.uk/pdbsum/2vrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vrs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIGC_ARVS1 SIGC_ARVS1] Structural protein responsible for cell attachment. Induces cell apoptosis.<ref>PMID:15033566</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vrs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vrs ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Avian reovirus fibre, a homo-trimer of the sigmaC protein, is a minor component of the avian reovirus outer capsid. It is anchored via a short N-terminal sequence to the inner capsid lambdaC pentamer, and its protruding globular C-terminal domain is responsible for primary host cell attachment. We have previously solved the structure of a receptor-binding fragment in which residues 160-191 form a triple beta-spiral and 196-326 a beta-barrel head domain. Here we have expressed, purified and crystallized a major sigmaC fragment comprising residues 117-326. Its structure, which was solved by molecular replacement using the previously determined receptor-binding domain structure and refined to 1.75 A (0.175 nm) resolution, reveals an alpha-helical triple coiled-coil connected to the previously solved structure by a zinc-ion-containing linker. The coiled-coil domain contains two chloride ion binding sites, as well as specific trimerization and registration sequences. The linker may act as a functionally important hinge.
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===STRUCTURE OF AVIAN REOVIRUS SIGMA C 117-326, C2 CRYSTAL FORM===
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Crystallographic structure of the alpha-helical triple coiled-coil domain of avian reovirus S1133 fibre.,Guardado-Calvo P, Fox GC, Llamas-Saiz AL, van Raaij MJ J Gen Virol. 2009 Mar;90(Pt 3):672-7. PMID:19218213<ref>PMID:19218213</ref>
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{{ABSTRACT_PUBMED_19218213}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vrs" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2vrs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Avian_orthoreovirus Avian orthoreovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRS OCA].
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019218213</ref><ref group="xtra">PMID:016511119</ref><ref group="xtra">PMID:016236316</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Avian orthoreovirus]]
[[Category: Avian orthoreovirus]]
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[[Category: Benavente, J.]]
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[[Category: Large Structures]]
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[[Category: Fox, G C.]]
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[[Category: Benavente J]]
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[[Category: Guardado-Calvo, P.]]
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[[Category: Fox GC]]
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[[Category: Llamas-Saiz, A L.]]
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[[Category: Guardado-Calvo P]]
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[[Category: Raaij, M J.Van.]]
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[[Category: Llamas-Saiz AL]]
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[[Category: Alpha-helical coiled coil]]
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[[Category: Van Raaij MJ]]
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[[Category: Beta-barrel]]
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[[Category: Receptor-binding]]
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[[Category: Triple beta-spiral]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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Current revision

Structure of avian reovirus sigmaC117-326, C2 crystal form

PDB ID 2vrs

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