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1zgs

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[[Image:1zgs.gif|left|200px]]<br /><applet load="1zgs" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1zgs, resolution 2.50&Aring;" />
 
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'''Parkia platycephala seed lectin in complex with 5-bromo-4-chloro-3-indolyl-a-D-mannose'''<br />
 
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==Overview==
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==Parkia platycephala seed lectin in complex with 5-bromo-4-chloro-3-indolyl-a-D-mannose==
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The crystal structures of the apo and mannose-bound Parkia platycephala seed lectin represent the first structure of a Mimosoideae lectin and a novel circular arrangement of beta-prism domains, and highlight the adaptability of the beta-prism fold as a building block in the evolution of plant lectins. The P.platycephala lectin is a dimer both in solution and in the crystals. Mannose binding to each of the three homologous carbohydrate-recognition domains of the lectin occurs through different modes, and restrains the flexibility of surface-exposed loops and residues involved in carbohydrate recognition. The planar array of carbohydrate-binding sites on the rim of the toroid-shaped structure of the P.platycephala lectin dimer immediately suggests a mechanism to promote multivalent interactions leading to cross-linking of carbohydrate ligands as part of the host strategy against phytopredators and pathogens. The cyclic structure of the P.platycephala lectin points to the convergent evolution of a structural principle for the construction of lectins involved in host defense or in attacking other organisms.
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<StructureSection load='1zgs' size='340' side='right'caption='[[1zgs]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1zgs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Parkia_platycephala Parkia platycephala]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZGS FirstGlance]. <br>
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1ZGS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Parkia_platycephala Parkia platycephala] with <scene name='pdbligand=XMM:'>XMM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGS OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zgs OCA], [https://pdbe.org/1zgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zgs RCSB], [https://www.ebi.ac.uk/pdbsum/1zgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zgs ProSAT]</span></td></tr>
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The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain., Gallego del Sol F, Nagano C, Cavada BS, Calvete JJ, J Mol Biol. 2005 Oct 28;353(3):574-83. Epub 2005 Sep 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16185708 16185708]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEC_PARPC LEC_PARPC] Mannose/glucose specific lectin. Shows agglutinating activity against rabbit erythrocytes.<ref>PMID:11502201</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/1zgs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zgs ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Parkia platycephala]]
[[Category: Parkia platycephala]]
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[[Category: Single protein]]
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[[Category: Calvete JJ]]
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[[Category: Calvete, J J.]]
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[[Category: Cavada BS]]
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[[Category: Cavada, B S.]]
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[[Category: Gallego del Sol F]]
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[[Category: Sol, F Gallego del.]]
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[[Category: XMM]]
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[[Category: beta prism]]
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[[Category: lectin]]
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[[Category: x-man]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:15:23 2008''
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Current revision

Parkia platycephala seed lectin in complex with 5-bromo-4-chloro-3-indolyl-a-D-mannose

PDB ID 1zgs

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