2k0p

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[[Image:2k0p.png|left|200px]]
 
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{{STRUCTURE_2k0p| PDB=2k0p | SCENE= }}
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==Determination of a Protein Structure in the Solid State from NMR Chemical Shifts==
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<StructureSection load='2k0p' size='340' side='right'caption='[[2k0p]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k0p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K0P FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k0p OCA], [https://pdbe.org/2k0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k0p RCSB], [https://www.ebi.ac.uk/pdbsum/2k0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k0p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPG1_STRSG SPG1_STRSG] Binds to the constant Fc region of IgG with high affinity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/2k0p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k0p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Solid-state NMR spectroscopy does not require proteins to form crystalline or soluble samples and can thus be applied under a variety of conditions, including precipitates, gels, and microcrystals. It has recently been shown that NMR chemical shifts can be used to determine the structures of the native states of proteins in solution. By considering the cases of two proteins, GB1 and SH3, we provide an initial demonstration here that this type of approach can be extended to the use of solid-state NMR chemical shifts to obtain protein structures in the solid state without the need for measuring interatomic distances.
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===Determination of a Protein Structure in the Solid State from NMR Chemical Shifts===
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Determination of protein structures in the solid state from NMR chemical shifts.,Robustelli P, Cavalli A, Vendruscolo M Structure. 2008 Dec 10;16(12):1764-9. PMID:19081052<ref>PMID:19081052</ref>
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{{ABSTRACT_PUBMED_19081052}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2k0p" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2k0p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0P OCA].
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*[[Protein G|Protein G]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019081052</ref><ref group="xtra">PMID:017907259</ref><ref group="xtra">PMID:017725352</ref><ref group="xtra">PMID:017535901</ref><references group="xtra"/>
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__TOC__
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[[Category: Bacteria]]
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</StructureSection>
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[[Category: Cavalli, A.]]
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[[Category: Large Structures]]
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[[Category: Robustelli, P.]]
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[[Category: Streptococcus sp. 'group G']]
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[[Category: Salvatella, X.]]
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[[Category: Cavalli A]]
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[[Category: Vendruscolo, M.]]
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[[Category: Robustelli P]]
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[[Category: Cell wall]]
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[[Category: Salvatella X]]
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[[Category: Chemical shift restraint]]
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[[Category: Vendruscolo M]]
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[[Category: Gb1]]
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[[Category: Igg-binding protein]]
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[[Category: Peptidoglycan-anchor]]
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[[Category: Protein binding]]
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[[Category: Secreted]]
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[[Category: Solid-state]]
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Current revision

Determination of a Protein Structure in the Solid State from NMR Chemical Shifts

PDB ID 2k0p

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