1zhu
From Proteopedia
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| - | [[Image:1zhu.gif|left|200px]]<br /><applet load="1zhu" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1zhu" /> | ||
| - | '''DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES'''<br /> | ||
| - | == | + | ==DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES== |
| + | <StructureSection load='1zhu' size='340' side='right'caption='[[1zhu]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1zhu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZHU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhu OCA], [https://pdbe.org/1zhu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zhu RCSB], [https://www.ebi.ac.uk/pdbsum/1zhu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zhu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
In certain contexts the DNA triplet GGA, when juxtaposed on opposite strands of a DNA duplex, shows the unusual property of pairing with itself in an antiparallel orientation to form the (GGA)2 motif. In this motif the central guanines do not pair but intercalate and stack between sheared G.A pairs. Similar studies with GCA triplets reveal that they do not form analogous paired (GCA)2 motifs but instead strongly promote formation of a hairpin, the structure of which is now reported here. The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases. | In certain contexts the DNA triplet GGA, when juxtaposed on opposite strands of a DNA duplex, shows the unusual property of pairing with itself in an antiparallel orientation to form the (GGA)2 motif. In this motif the central guanines do not pair but intercalate and stack between sheared G.A pairs. Similar studies with GCA triplets reveal that they do not form analogous paired (GCA)2 motifs but instead strongly promote formation of a hairpin, the structure of which is now reported here. The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases. | ||
| - | + | Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA.,Zhu L, Chou SH, Xu J, Reid BR Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:7583654<ref>PMID:7583654</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 1zhu" style="background-color:#fffaf0;"></div> |
| - | [[Category: Chou | + | == References == |
| - | [[Category: Reid | + | <references/> |
| - | [[Category: Xu | + | __TOC__ |
| - | [[Category: Zhu | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Chou S-H]] | |
| - | + | [[Category: Reid BR]] | |
| - | + | [[Category: Xu J]] | |
| - | + | [[Category: Zhu L]] | |
| - | + | ||
Current revision
DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES
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Categories: Large Structures | Chou S-H | Reid BR | Xu J | Zhu L
