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1hjz

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[[Image:1hjz.gif|left|200px]]<br />
 
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<applet load="1hjz" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hjz, resolution 1.7&Aring;" />
 
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'''CRYSTAL STRUCTURE OF AF1521 PROTEIN CONTAINING A MACROH2A DOMAIN'''<br />
 
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==Overview==
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==Crystal structure of AF1521 protein containing a macroH2A domain==
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MacroH2A is an unusual histone H2A variant that has an extensive, C-terminal tail that comprises approximately two thirds of the protein., The C-terminal non-histone domain of macroH2A is also found in a number of, other proteins and has been termed the macro domain. Here we report the, crystal structure to 1.7A of AF1521, a protein consisting of a stand-alone, macro domain from Archaeoglobus fulgidus. The structure has a mixed, alpha/beta fold that closely resembles the N-terminal DNA binding domain, of the Escherichia coli leucine aminopeptidase PepA. The structure also, shows some similarity to members of the P-loop family of nucleotide, hydrolases.
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<StructureSection load='1hjz' size='340' side='right'caption='[[1hjz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1hjz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HJZ FirstGlance]. <br>
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1HJZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]] with MES as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HJZ OCA]].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hjz OCA], [https://pdbe.org/1hjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hjz RCSB], [https://www.ebi.ac.uk/pdbsum/1hjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hjz ProSAT]</span></td></tr>
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The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A., Allen MD, Buckle AM, Cordell SC, Lowe J, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):503-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12842467 12842467]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Y1521_ARCFU Y1521_ARCFU] Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Catalyzes removal of a phosphate group from ADP-ribose 1''-phosphate (Appr1p), but with low efficiency.<ref>PMID:23474712</ref> <ref>PMID:15902274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/1hjz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hjz ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Allen, M.D.]]
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[[Category: Allen MD]]
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[[Category: Buckle, A.M.]]
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[[Category: Buckle AM]]
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[[Category: Bycroft, M.]]
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[[Category: Bycroft M]]
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[[Category: Cordell, S.C.]]
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[[Category: Cordell SC]]
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[[Category: Lowe, J.]]
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[[Category: Lowe J]]
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[[Category: MES]]
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[[Category: crystal structure p-loop nucleotide hydrolase]]
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[[Category: histone macroh2a]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:37:17 2007''
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Current revision

Crystal structure of AF1521 protein containing a macroH2A domain

PDB ID 1hjz

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