4izg

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'''Unreleased structure'''
 
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The entry 4izg is ON HOLD
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==Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound cis-4oh-d-proline betaine (product)==
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<StructureSection load='4izg' size='340' side='right'caption='[[4izg]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4izg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paracoccus_denitrificans_PD1222 Paracoccus denitrificans PD1222]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IZG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4OP:(2S,4S)-2-CARBOXY-4-HYDROXY-1,1-DIMETHYLPYRROLIDINIUM'>4OP</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4izg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4izg OCA], [https://pdbe.org/4izg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4izg RCSB], [https://www.ebi.ac.uk/pdbsum/4izg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4izg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HPBD_PARDP HPBD_PARDP] Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L-proline betaine.<ref>PMID:24056934</ref>
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Authors: Vetting, M.W., Toro, R., Bhosle, R., Wasserman, S.R., Morisco, L.L., Sojitra, S., Chamala, S., Kar, A., LaFleur, J., Villigas, G., Evans, B., Hammonds, J., Gizzi, A., Stead, M., Hillerich, B., Love, J., Seidel, R.D., Bonanno, J.B., Gerlt, J.A., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC)
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==See Also==
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*[[Enolase 3D structures|Enolase 3D structures]]
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Description: Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound cis-4oh-d-proline betaine (product)
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*[[Mandelate racemase/muconate lactonizing enzyme 3D structures|Mandelate racemase/muconate lactonizing enzyme 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Paracoccus denitrificans PD1222]]
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[[Category: Almo SC]]
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[[Category: Bhosle R]]
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[[Category: Bonanno JB]]
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[[Category: Chamala S]]
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[[Category: Evans B]]
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[[Category: Gerlt JA]]
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[[Category: Gizzi A]]
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[[Category: Hammonds J]]
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[[Category: Hillerich B]]
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[[Category: Kar A]]
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[[Category: LaFleur J]]
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[[Category: Love J]]
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[[Category: Morisco LL]]
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[[Category: Seidel RD]]
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[[Category: Sojitra S]]
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[[Category: Stead M]]
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[[Category: Toro R]]
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[[Category: Vetting MW]]
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[[Category: Villigas G]]
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[[Category: Wasserman SR]]

Current revision

Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound cis-4oh-d-proline betaine (product)

PDB ID 4izg

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