1zm0

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[[Image:1zm0.gif|left|200px]]<br /><applet load="1zm0" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1zm0, resolution 2.100&Aring;" />
 
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'''Crystal Structure of the Carboxyl Terminal PH Domain of Pleckstrin To 2.1 Angstroms'''<br />
 
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==Overview==
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==Crystal Structure of the Carboxyl Terminal PH Domain of Pleckstrin To 2.1 Angstroms==
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Pleckstrin is an important intracellular protein involved in the phosphoinositide-signalling pathways of platelet activation. This protein contains both N- and C-terminal pleckstrin-homology (PH) domains (N-PH and C-PH). The crystal structure of C-PH was solved by molecular replacement and refined at 2.1 Angstroms resolution. Two molecules were observed within the asymmetric unit and it is proposed that the resulting dimer interface could contribute to the previously observed oligomerization of pleckstrin in resting platelets. Structural comparisons between the phosphoinositide-binding loops of the C-PH crystal structure and the PH domains of DAPP1 and TAPP1, the N-terminal PH domain of pleckstrin and a recently described solution structure of C-PH are presented and discussed.
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<StructureSection load='1zm0' size='340' side='right'caption='[[1zm0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1zm0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZM0 FirstGlance]. <br>
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Known disease associated with this structure: Age-related maculopathy, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607772 607772]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zm0 OCA], [https://pdbe.org/1zm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zm0 RCSB], [https://www.ebi.ac.uk/pdbsum/1zm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zm0 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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1ZM0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZM0 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PLEK_HUMAN PLEK_HUMAN] Major protein kinase C substrate of platelets.
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==Reference==
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== Evolutionary Conservation ==
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Structure of the carboxy-terminal PH domain of pleckstrin at 2.1 Angstroms., Jackson SG, Zhang Y, Bao X, Zhang K, Summerfield R, Haslam RJ, Junop MS, Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):324-30. Epub 2006, Feb 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16510979 16510979]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zm/1zm0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zm0 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Haslam, R J.]]
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[[Category: Haslam RJ]]
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[[Category: Jackson, S G.]]
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[[Category: Jackson SG]]
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[[Category: Junop, M S.]]
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[[Category: Junop MS]]
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[[Category: Summerfield, R.]]
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[[Category: Summerfield R]]
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[[Category: Zhang, K.]]
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[[Category: Zhang K]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: beta sandwich]]
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[[Category: ph domain]]
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[[Category: pleckstrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:16:53 2008''
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Current revision

Crystal Structure of the Carboxyl Terminal PH Domain of Pleckstrin To 2.1 Angstroms

PDB ID 1zm0

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