3vzv

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[[Image:3vzv.jpg|left|200px]]
 
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{{STRUCTURE_3vzv| PDB=3vzv | SCENE= }}
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==Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor==
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<StructureSection load='3vzv' size='340' side='right'caption='[[3vzv]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VZV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VZV:1-{[(5R,6S)-5,6-BIS(4-CHLOROPHENYL)-6-METHYL-3-(PROPAN-2-YL)-5,6-DIHYDROIMIDAZO[2,1-B][1,3]THIAZOL-2-YL]CARBONYL}-N,N-DIMETHYL-L-PROLINAMIDE'>VZV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vzv OCA], [https://pdbe.org/3vzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vzv RCSB], [https://www.ebi.ac.uk/pdbsum/3vzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vzv ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
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== Function ==
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[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
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===Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor===
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==See Also==
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*[[MDM2 3D structures|MDM2 3D structures]]
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{{ABSTRACT_PUBMED_23266121}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3vzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZV OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Katakura, S.]]
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[[Category: Large Structures]]
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[[Category: Kawato, H.]]
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[[Category: Katakura S]]
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[[Category: Miyazaki, M.]]
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[[Category: Kawato H]]
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[[Category: Naito, H.]]
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[[Category: Miyazaki M]]
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[[Category: Okayama, T.]]
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[[Category: Naito H]]
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[[Category: Shimizu, H.]]
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[[Category: Okayama T]]
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[[Category: Soga, T.]]
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[[Category: Shimizu H]]
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[[Category: Sugimoto, Y.]]
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[[Category: Soga T]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Sugimoto Y]]
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[[Category: P53]]
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[[Category: Ubiquitin-protein ligase e3 mdm2]]
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Current revision

Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor

PDB ID 3vzv

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