4drj

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[[Image:4drj.jpg|left|200px]]
 
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{{STRUCTURE_4drj| PDB=4drj | SCENE= }}
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==o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR==
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<StructureSection load='4drj' size='340' side='right'caption='[[4drj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4drj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drj OCA], [https://pdbe.org/4drj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drj RCSB], [https://www.ebi.ac.uk/pdbsum/4drj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP4_HUMAN FKBP4_HUMAN] Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.<ref>PMID:1279700</ref> <ref>PMID:1376003</ref> <ref>PMID:2378870</ref> <ref>PMID:19945390</ref> <ref>PMID:21730050</ref>
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===o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR===
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
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{{ABSTRACT_PUBMED_23358420}}
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4drj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRJ OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Bracher, A.]]
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[[Category: Bracher A]]
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[[Category: Hausch, F.]]
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[[Category: Hausch F]]
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[[Category: Maerz, A M.]]
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[[Category: Maerz AM]]
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[[Category: Cancer]]
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[[Category: Fk-506 binding domain]]
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[[Category: Hsp90 cochaperone]]
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[[Category: Immunophilin]]
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[[Category: Immunosuppression]]
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[[Category: Isomerase-transferase complex]]
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[[Category: Kinase]]
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[[Category: Mammalian target of rapamycin]]
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[[Category: Peptidyl-prolyl isomerase]]
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[[Category: Signalling]]
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Current revision

o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR

PDB ID 4drj

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