3epp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3epp" [edit=sysop:move=sysop])
Current revision (09:48, 21 February 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3epp.png|left|200px]]
 
-
{{STRUCTURE_3epp| PDB=3epp | SCENE= }}
+
==Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin==
-
 
+
<StructureSection load='3epp' size='340' side='right'caption='[[3epp]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
-
===Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3epp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPP FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
-
==About this Structure==
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr>
-
[[3epp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPP OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epp OCA], [https://pdbe.org/3epp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epp RCSB], [https://www.ebi.ac.uk/pdbsum/3epp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epp ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epp_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epp ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Amaya, M F.]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Amaya MF]]
-
[[Category: Botchkarev, A.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C.]]
+
[[Category: Botchkarev A]]
-
[[Category: Edwards, A M.]]
+
[[Category: Bountra C]]
-
[[Category: Loppnau, P.]]
+
[[Category: Edwards AM]]
-
[[Category: Min, J.]]
+
[[Category: Loppnau P]]
-
[[Category: Plotnikov, A N.]]
+
[[Category: Min J]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Plotnikov AN]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Wu, H.]]
+
[[Category: Wu H]]
-
[[Category: Zeng, H.]]
+
[[Category: Zeng H]]
-
[[Category: Mrna cap guanine-n7 methyltransferase]]
+
-
[[Category: Mrna capping]]
+
-
[[Category: Mrna processing]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Rna-binding]]
+
-
[[Category: Rnmt]]
+
-
[[Category: S-adenosyl-l-methionine]]
+
-
[[Category: Sgc]]
+
-
[[Category: Sinefungin]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin

PDB ID 3epp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3epp"
Personal tools