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3era

From Proteopedia

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[[Image:3era.png|left|200px]]
 
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{{STRUCTURE_3era| PDB=3era | SCENE= }}
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==RECOMBINANT ERABUTOXIN A (S8T MUTANT)==
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<StructureSection load='3era' size='340' side='right'caption='[[3era]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===RECOMBINANT ERABUTOXIN A (S8T MUTANT)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3era]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Laticauda_semifasciata Laticauda semifasciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ERA FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10691969}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3era FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3era OCA], [https://pdbe.org/3era PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3era RCSB], [https://www.ebi.ac.uk/pdbsum/3era PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3era ProSAT]</span></td></tr>
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[[3era]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Laticauda_semifasciata Laticauda semifasciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERA OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/3S1EA_LATSE 3S1EA_LATSE] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs) (tested on Torpedo marmorata, Kd=21 uM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (tested on chimeric alpha-7/CHRNA7, Kd=0.07 nM) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission (PubMed:7721859). Blocks the extracellular increase of dopamine evoked by nicotine at 4.2 uM concentrations (PubMed:9840221). In vivo, produces peripheral paralysis.<ref>PMID:7721859</ref> <ref>PMID:9305882</ref> <ref>PMID:9840221</ref>
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<ref group="xtra">PMID:010691969</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/3era_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3era ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Laticauda semifasciata]]
[[Category: Laticauda semifasciata]]
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[[Category: Arnoux, B.]]
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[[Category: Arnoux B]]
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[[Category: Ducruix, A.]]
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[[Category: Ducruix A]]
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[[Category: Gaucher, J F.]]
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[[Category: Gaucher JF]]
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[[Category: Menez, A.]]
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[[Category: Menez A]]
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[[Category: Menez, R.]]
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[[Category: Menez R]]
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[[Category: Neurotoxin]]
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[[Category: Postsynaptic neurotoxin]]
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[[Category: Snake neurotoxin]]
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[[Category: Venom]]
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Current revision

RECOMBINANT ERABUTOXIN A (S8T MUTANT)

PDB ID 3era

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