3et8

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[[Image:3et8.png|left|200px]]
 
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{{STRUCTURE_3et8| PDB=3et8 | SCENE= }}
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==A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6054==
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<StructureSection load='3et8' size='340' side='right'caption='[[3et8]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3et8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ET8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ET8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NCL:3,6-BIS{3-(3-[(3R)-METHYLPIPERIDINO)]PROPIONAMIDO}ACRIDINE'>NCL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3et8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3et8 OCA], [https://pdbe.org/3et8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3et8 RCSB], [https://www.ebi.ac.uk/pdbsum/3et8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3et8 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.
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===A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6054===
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Selectivity in Ligand Recognition of G-Quadruplex Loops (dagger).,Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S Biochemistry. 2009 Feb 4. PMID:19173611<ref>PMID:19173611</ref>
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{{ABSTRACT_PUBMED_19173611}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3et8" style="background-color:#fffaf0;"></div>
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[[3et8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ET8 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019173611</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Campbell, N H.]]
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[[Category: Large Structures]]
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[[Category: Neidle, S.]]
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[[Category: Campbell NH]]
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[[Category: Parkinson, G.]]
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[[Category: Neidle S]]
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[[Category: Anti-parallel]]
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[[Category: Parkinson G]]
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[[Category: Bimolecular]]
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[[Category: Bsu-6054]]
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[[Category: Bsu6054]]
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[[Category: Dna]]
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[[Category: G-quadruplex]]
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[[Category: Macromolecule]]
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[[Category: Oxytricha nova]]
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[[Category: Quadruplex]]
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Current revision

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6054

PDB ID 3et8

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