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3evi

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[[Image:3evi.png|left|200px]]
 
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{{STRUCTURE_3evi| PDB=3evi | SCENE= }}
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==Crystal structure of the thioredoxin-fold domain of human phosducin-like protein 2==
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<StructureSection load='3evi' size='340' side='right'caption='[[3evi]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3evi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EVI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3evi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3evi OCA], [https://pdbe.org/3evi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3evi RCSB], [https://www.ebi.ac.uk/pdbsum/3evi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3evi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDCL2_HUMAN PDCL2_HUMAN] May play a role in germ cell maturation (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/3evi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3evi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human phosducin-like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. The X-ray crystal structure of the Trx-fold domain of hPDCL2 was solved at 2.70 A resolution and resembled the Trx-fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence.
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===Crystal structure of the thioredoxin-fold domain of human phosducin-like protein 2===
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Structure of the thioredoxin-fold domain of human phosducin-like protein 2.,Lou X, Bao R, Zhou CZ, Chen Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt, 2):67-70. Epub 2009 Jan 31. PMID:19193988<ref>PMID:19193988</ref>
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{{ABSTRACT_PUBMED_19193988}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3evi" style="background-color:#fffaf0;"></div>
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[[3evi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EVI OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019193988</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bao, R.]]
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[[Category: Large Structures]]
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[[Category: Chen, Y.]]
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[[Category: Bao R]]
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[[Category: Lou, X.]]
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[[Category: Chen Y]]
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[[Category: Zhou, C.]]
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[[Category: Lou X]]
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[[Category: Alpha beta]]
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[[Category: Zhou C]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of the thioredoxin-fold domain of human phosducin-like protein 2

PDB ID 3evi

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