3epo

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[[Image:3epo.png|left|200px]]
 
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{{STRUCTURE_3epo| PDB=3epo | SCENE= }}
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==Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P==
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<StructureSection load='3epo' size='340' side='right'caption='[[3epo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3epo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPO FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18953358}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MP5:(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL+DIHYDROGEN+PHOSPHATE'>MP5</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epo OCA], [https://pdbe.org/3epo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epo RCSB], [https://www.ebi.ac.uk/pdbsum/3epo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epo ProSAT]</span></td></tr>
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[[3epo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPO OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/THIC_CAUVC THIC_CAUVC] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.<ref>PMID:18953358</ref>
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<ref group="xtra">PMID:018953358</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epo ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caulobacter vibrioides]]
[[Category: Caulobacter vibrioides]]
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[[Category: Begley, T P.]]
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[[Category: Large Structures]]
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[[Category: Booker, S J.]]
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[[Category: Begley TP]]
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[[Category: Chatterjee, A.]]
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[[Category: Booker SJ]]
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[[Category: Ealick, S E.]]
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[[Category: Chatterjee A]]
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[[Category: Grove, T L.]]
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[[Category: Ealick SE]]
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[[Category: Krebs, C.]]
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[[Category: Grove TL]]
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[[Category: Lee, M.]]
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[[Category: Krebs C]]
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[[Category: Li, S.]]
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[[Category: Lee M]]
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[[Category: Zhang, Y.]]
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[[Category: Li S]]
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[[Category: Alpha-beta barrel]]
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[[Category: Zhang Y]]
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[[Category: Biosynthetic protein]]
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[[Category: Sam superfamily]]
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[[Category: Thiamine biosynthesis]]
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Current revision

Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P

PDB ID 3epo

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