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1zsy

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[[Image:1zsy.gif|left|200px]]<br /><applet load="1zsy" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1zsy, resolution 1.75&Aring;" />
 
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'''The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)'''<br />
 
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==About this Structure==
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==The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)==
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1ZSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Trans-2-enoyl-CoA_reductase_(NADPH) Trans-2-enoyl-CoA reductase (NADPH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.38 1.3.1.38] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSY OCA].
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<StructureSection load='1zsy' size='340' side='right'caption='[[1zsy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZSY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zsy OCA], [https://pdbe.org/1zsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zsy RCSB], [https://www.ebi.ac.uk/pdbsum/1zsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zsy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MECR_HUMAN MECR_HUMAN] Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zsy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zsy ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Trans-2-enoyl-CoA reductase (NADPH)]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Edwards A]]
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[[Category: Delft, F von.]]
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[[Category: Johansson C]]
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[[Category: Edwards, A.]]
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[[Category: Kavanagh KL]]
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[[Category: Johansson, C.]]
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[[Category: Lukacik P]]
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[[Category: Kavanagh, K L.]]
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[[Category: Oppermann U]]
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[[Category: Lukacik, P.]]
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[[Category: Shafqat N]]
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[[Category: Oppermann, U.]]
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[[Category: Smee C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Shafqat, N.]]
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[[Category: Von Delft F]]
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[[Category: Smee, C.]]
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[[Category: Sundstrom, M.]]
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[[Category: GOL]]
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[[Category: SO4]]
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[[Category: 2-enoyl thioester reductase]]
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[[Category: fatty acid synthesis (type 2)]]
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[[Category: medium-chain dehydrogenase/reductase]]
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[[Category: oxidoreductase]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:18:44 2008''
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Current revision

The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)

PDB ID 1zsy

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