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1zx1
From Proteopedia
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| - | [[Image:1zx1.gif|left|200px]]<br /><applet load="1zx1" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1zx1, resolution 2.16Å" /> | ||
| - | '''Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954'''<br /> | ||
| - | == | + | ==Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954== |
| - | + | <StructureSection load='1zx1' size='340' side='right'caption='[[1zx1]], [[Resolution|resolution]] 2.16Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1zx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZX1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16Å</td></tr> | |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zx1 OCA], [https://pdbe.org/1zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/1zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zx1 ProSAT]</span></td></tr> | |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/1zx1_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | [ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zx1 ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
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| - | + | ==See Also== | |
| + | *[[Quinone reductase|Quinone reductase]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith C]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Gunther U]] | ||
| + | [[Category: Jansson A]] | ||
| + | [[Category: Kavanagh K]] | ||
| + | [[Category: Kerr D]] | ||
| + | [[Category: Knox R]] | ||
| + | [[Category: Ludwig C]] | ||
| + | [[Category: Oppermann U]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Walton R]] | ||
| + | [[Category: Wu X]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Edwards A | Gunther U | Jansson A | Kavanagh K | Kerr D | Knox R | Ludwig C | Oppermann U | Sundstrom M | Walton R | Wu X | Von Delft F
