1zx1

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[[Image:1zx1.gif|left|200px]]<br /><applet load="1zx1" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1zx1, resolution 2.16&Aring;" />
 
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'''Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954'''<br />
 
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==About this Structure==
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==Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954==
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1ZX1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=FAD:'>FAD</scene> and <scene name='pdbligand=CB1:'>CB1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZX1 OCA].
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<StructureSection load='1zx1' size='340' side='right'caption='[[1zx1]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1zx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZX1 FirstGlance]. <br>
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[[Category: Arrowsmith, C.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
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[[Category: Delft, F von.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Edwards, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zx1 OCA], [https://pdbe.org/1zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/1zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zx1 ProSAT]</span></td></tr>
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[[Category: Gunther, U.]]
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</table>
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[[Category: Jansson, A.]]
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== Function ==
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[[Category: Kavanagh, K.]]
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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[[Category: Kerr, D.]]
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== Evolutionary Conservation ==
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[[Category: Knox, R.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Ludwig, C.]]
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Check<jmol>
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[[Category: Oppermann, U.]]
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<jmolCheckbox>
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[[Category: SGC, Structural Genomics Consortium.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/1zx1_consurf.spt"</scriptWhenChecked>
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[[Category: Sundstrom, M.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Walton, R.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Wu, X.]]
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</jmolCheckbox>
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[[Category: CB1]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zx1 ConSurf].
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[[Category: FAD]]
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<div style="clear:both"></div>
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[[Category: ZN]]
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[[Category: 4-dinitrobenamide (cb1954)]]
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[[Category: 5-(aziridin-1-yl)-2]]
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[[Category: dihydronicotinamide ribose]]
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[[Category: electrondonor]]
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[[Category: flavin-containing]]
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[[Category: quinone oxidoreductase 2]]
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[[Category: reductions of quinones]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:19:58 2008''
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==See Also==
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*[[Quinone reductase|Quinone reductase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards A]]
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[[Category: Gunther U]]
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[[Category: Jansson A]]
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[[Category: Kavanagh K]]
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[[Category: Kerr D]]
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[[Category: Knox R]]
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[[Category: Ludwig C]]
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[[Category: Oppermann U]]
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[[Category: Sundstrom M]]
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[[Category: Walton R]]
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[[Category: Wu X]]
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[[Category: Von Delft F]]

Current revision

Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954

PDB ID 1zx1

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