3vaj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:34, 1 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3vaj.jpg|left|200px]]
 
-
{{STRUCTURE_3vaj| PDB=3vaj | SCENE= }}
+
==Structure of U2AF65 variant with BrU5C6 DNA==
-
 
+
<StructureSection load='3vaj' size='340' side='right'caption='[[3vaj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
===Structure of U2AF65 variant with BrU5C6 DNA===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3vaj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VAJ FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_23376934}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=CPQ:N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE'>CPQ</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vaj OCA], [https://pdbe.org/3vaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vaj RCSB], [https://www.ebi.ac.uk/pdbsum/3vaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vaj ProSAT]</span></td></tr>
-
[[3vaj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VAJ OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Jenkins, J L.]]
+
[[Category: Large Structures]]
-
[[Category: Kielkopf, C L.]]
+
[[Category: Jenkins JL]]
-
[[Category: Rna binding protein]]
+
[[Category: Kielkopf CL]]
-
[[Category: Rna binding protein-dna complex]]
+
-
[[Category: Rna recognition motif]]
+
-
[[Category: Rna splicing factor]]
+

Current revision

Structure of U2AF65 variant with BrU5C6 DNA

PDB ID 3vaj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3vaj"
Personal tools