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4hxw

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[[Image:4hxw.jpg|left|200px]]
 
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{{STRUCTURE_4hxw| PDB=4hxw | SCENE= }}
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==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.==
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<StructureSection load='4hxw' size='340' side='right'caption='[[4hxw]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HXW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1A0:(3R)-1-[5-CHLORO-6-ETHYL-2-(PYRIDO[2,3-B]PYRAZIN-7-YLSULFANYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL]PYRROLIDIN-3-AMINE'>1A0</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hxw OCA], [https://pdbe.org/4hxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hxw RCSB], [https://www.ebi.ac.uk/pdbsum/4hxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hxw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA]
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===Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.===
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==See Also==
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
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{{ABSTRACT_PUBMED_23352267}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Enterococcus faecalis V583]]
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[[4hxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis_v583 Enterococcus faecalis v583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HXW OCA].
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[[Category: Large Structures]]
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[[Category: Enterococcus faecalis v583]]
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[[Category: Bensen DC]]
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[[Category: Bensen, D C.]]
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[[Category: Tari LW]]
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[[Category: Tari, L W.]]
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[[Category: Trzoss M]]
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[[Category: Trzoss, M.]]
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[[Category: Atp-binding]]
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[[Category: Atp-binding domain]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Topoisomerase]]
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Current revision

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

PDB ID 4hxw

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