4hym

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:48, 1 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4hym.jpg|left|200px]]
 
-
{{STRUCTURE_4hym| PDB=4hym | SCENE= }}
+
==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.==
 +
<StructureSection load='4hym' size='340' side='right'caption='[[4hym]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4hym]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._holarctica_LVS Francisella tularensis subsp. holarctica LVS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HYM FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CJC:7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)PYRIDO[2,3-B]PYRAZIN-2(1H)-ONE'>CJC</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hym OCA], [https://pdbe.org/4hym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hym RCSB], [https://www.ebi.ac.uk/pdbsum/4hym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hym ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PARE_FRATH PARE_FRATH] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:23352267, PubMed:23294697, PubMed:24386374). Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00938]<ref>PMID:23352267</ref> <ref>PMID:24386374</ref> <ref>PMID:23294697</ref>
-
===Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.===
+
==See Also==
-
 
+
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
-
{{ABSTRACT_PUBMED_23352267}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[4hym]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis_subsp._holarctica_lvs Francisella tularensis subsp. holarctica lvs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HYM OCA].
+
</StructureSection>
-
[[Category: Francisella tularensis subsp. holarctica lvs]]
+
[[Category: Francisella tularensis subsp. holarctica LVS]]
-
[[Category: Bensen, D C.]]
+
[[Category: Large Structures]]
-
[[Category: Creighton, C J.]]
+
[[Category: Bensen DC]]
-
[[Category: Kwan, B.]]
+
[[Category: Creighton CJ]]
-
[[Category: Tari, L W.]]
+
[[Category: Kwan B]]
-
[[Category: Atp-binding]]
+
[[Category: Tari LW]]
-
[[Category: Atp-binding domain]]
+
-
[[Category: Isomerase-isomerase inhibitor complex]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Topoisomerase]]
+

Current revision

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

PDB ID 4hym

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4hym"
Personal tools