4hsu

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[[Image:4hsu.jpg|left|200px]]
 
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{{STRUCTURE_4hsu| PDB=4hsu | SCENE= }}
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==Crystal structure of LSD2-NPAC with H3(1-26)in space group P21==
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<StructureSection load='4hsu' size='340' side='right'caption='[[4hsu]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hsu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HSU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.988&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsu OCA], [https://pdbe.org/4hsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hsu RCSB], [https://www.ebi.ac.uk/pdbsum/4hsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM1B_HUMAN KDM1B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity).
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===Crystal structure of LSD2-NPAC with H3(1-26)in space group P21===
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==See Also==
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*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4hsu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSU OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, F.]]
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[[Category: Large Structures]]
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[[Category: Dong, Z.]]
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[[Category: Xenopus laevis]]
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[[Category: Fang, J.]]
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[[Category: Chen F]]
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[[Category: Xu, Y.]]
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[[Category: Dong Z]]
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[[Category: Histone demethylase]]
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[[Category: Fang J]]
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[[Category: Oxidoreductase]]
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[[Category: Xu Y]]

Current revision

Crystal structure of LSD2-NPAC with H3(1-26)in space group P21

PDB ID 4hsu

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