4ijd

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[[Image:4ijd.jpg|left|200px]]
 
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{{STRUCTURE_4ijd| PDB=4ijd | SCENE= }}
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==Crystal structure of methyltransferase domain of human PR domain-containing protein 9==
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<StructureSection load='4ijd' size='340' side='right'caption='[[4ijd]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ijd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijd OCA], [https://pdbe.org/4ijd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijd RCSB], [https://www.ebi.ac.uk/pdbsum/4ijd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).
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===Crystal structure of methyltransferase domain of human PR domain-containing protein 9===
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4ijd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJD OCA].
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Brown, P J.]]
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[[Category: Bountra C]]
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[[Category: Dombrovski, L.]]
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[[Category: Brown PJ]]
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[[Category: Dong, A.]]
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[[Category: Dombrovski L]]
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[[Category: Edwards, A M.]]
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[[Category: Dong A]]
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[[Category: Li, Y.]]
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[[Category: Edwards AM]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Li Y]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Methyltransferase]]
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[[Category: Prdm9]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Crystal structure of methyltransferase domain of human PR domain-containing protein 9

PDB ID 4ijd

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