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3f69

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[[Image:3f69.png|left|200px]]
 
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{{STRUCTURE_3f69| PDB=3f69 | SCENE= }}
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==Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720==
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<StructureSection load='3f69' size='340' side='right'caption='[[3f69]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3f69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F69 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=XDR:HEXYL+(5S,6R,8R)-6-HYDROXY-5-METHYL-13-OXO-5,6,7,8-TETRAHYDRO-13H-5,8-EPOXY-4B,8A,14-TRIAZADIBENZO[B,H]CYCLOOCTA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACENE-6-CARBOXYLATE'>XDR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f69 OCA], [https://pdbe.org/3f69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f69 RCSB], [https://www.ebi.ac.uk/pdbsum/3f69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f69 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PKNB_MYCTU PKNB_MYCTU] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:15978616</ref> <ref>PMID:15987910</ref> <ref>PMID:16817899</ref> <ref>PMID:16980473</ref> <ref>PMID:16436437</ref> <ref>PMID:19826007</ref> <ref>PMID:19121323</ref> <ref>PMID:20025669</ref> <ref>PMID:21423706</ref> <ref>PMID:22275220</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/3f69_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f69 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720===
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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{{ABSTRACT_PUBMED_19008858}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3f69]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F69 OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:019008858</ref><references group="xtra"/>
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Alber, T.]]
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[[Category: Mieczkowski, C A.]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Atp-binding]]
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[[Category: Cocrystallization of pknb kinase domain and inhibitor]]
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[[Category: Kinase]]
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[[Category: Kt5720]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Nucleotide-binding]]
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[[Category: Alber T]]
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[[Category: Phosphoprotein]]
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[[Category: Mieczkowski CA]]
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[[Category: Pknb]]
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[[Category: Protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Structual genomic]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720

PDB ID 3f69

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