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217d

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[[Image:217d.gif|left|200px]]<br /><applet load="217d" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="217d, resolution 1.700&Aring;" />
 
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'''CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN==
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Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with drugs, peptides or proteins.
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<StructureSection load='217d' size='340' side='right'caption='[[217d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[217d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=217D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=217D FirstGlance]. <br>
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217D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DMY:'>DMY</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=217D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMY:DISTAMYCIN+A'>DMY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=217d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=217d OCA], [https://pdbe.org/217d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=217d RCSB], [https://www.ebi.ac.uk/pdbsum/217d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=217d ProSAT]</span></td></tr>
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Crystal structures of B-form DNA-RNA chimers complexed with distamycin., Chen X, Ramakrishnan B, Sundaralingam M, Nat Struct Biol. 1995 Sep;2(9):733-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7552741 7552741]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Chen, X.]]
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</StructureSection>
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[[Category: Ramakrishnan, B.]]
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[[Category: Large Structures]]
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[[Category: Sundaralingam, M.]]
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[[Category: Chen X]]
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[[Category: DMY]]
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[[Category: Ramakrishnan B]]
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[[Category: MG]]
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[[Category: Sundaralingam M]]
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[[Category: b-dna/rna]]
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[[Category: complexed with drug]]
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[[Category: double helix]]
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[[Category: modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:21:03 2008''
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Current revision

CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN

PDB ID 217d

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