3fd4

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[[Image:3fd4.png|left|200px]]
 
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{{STRUCTURE_3fd4| PDB=3fd4 | SCENE= }}
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==Crystal Structure of Epstein-Barr virus gp42 protein==
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<StructureSection load='3fd4' size='340' side='right'caption='[[3fd4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3fd4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FD4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fd4 OCA], [https://pdbe.org/3fd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fd4 RCSB], [https://www.ebi.ac.uk/pdbsum/3fd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fd4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GP42_EBVB9 GP42_EBVB9] Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells.<ref>PMID:12042810</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fd/3fd4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fd4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Epstein-Barr virus requires glycoproteins gH/gL, gB, and gp42 to fuse its lipid envelope with B cells. Gp42 is a type II membrane protein consisting of a flexible N-terminal region, which binds gH/gL, and a C-terminal lectin-like domain that binds to the B-cell entry receptor human leukocyte antigen (HLA) class II. Gp42 triggers membrane fusion after HLA binding, a process that requires simultaneous binding to gH/gL and a functional hydrophobic pocket in the lectin domain adjacent to the HLA binding site. Here we present the structure of gp42 in its unbound form. Comparisons to the previously determined structure of a gp42:HLA complex reveals additional N-terminal residues forming part of the gH/gL binding site and structural changes in the receptor binding domain. Although the core of the lectin domain remains similar, significant shifts in two loops and an alpha helix bordering the essential hydrophobic pocket suggest a structural mechanism for triggering fusion.
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===Crystal Structure of Epstein-Barr virus gp42 protein===
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Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry.,Kirschner AN, Sorem J, Longnecker R, Jardetzky TS Structure. 2009 Feb 13;17(2):223-33. PMID:19217393<ref>PMID:19217393</ref>
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{{ABSTRACT_PUBMED_19217393}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3fd4" style="background-color:#fffaf0;"></div>
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[[3fd4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FD4 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019217393</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Viruses]]
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[[Category: Human herpesvirus 4 strain B95-8]]
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[[Category: Jardetzky, T.]]
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[[Category: Large Structures]]
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[[Category: Kirschner, A.]]
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[[Category: Jardetzky T]]
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[[Category: C type lectin]]
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[[Category: Kirschner A]]
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[[Category: Herpesvirus]]
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[[Category: Host-virus interaction]]
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[[Category: Lectin]]
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[[Category: Membrane]]
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[[Category: Membrane fusion]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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[[Category: Virus entry]]
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Current revision

Crystal Structure of Epstein-Barr virus gp42 protein

PDB ID 3fd4

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