3fmd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3fmd" [edit=sysop:move=sysop])
Current revision (06:48, 6 September 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3fmd.png|left|200px]]
 
-
{{STRUCTURE_3fmd| PDB=3fmd | SCENE= }}
+
==Crystal Structure of Human Haspin with an Isoquinoline ligand==
 +
<StructureSection load='3fmd' size='340' side='right'caption='[[3fmd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3fmd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FMD FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IQB:N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE+SULFONAMIDE'>IQB</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmd OCA], [https://pdbe.org/3fmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fmd RCSB], [https://www.ebi.ac.uk/pdbsum/3fmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fmd ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fmd_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fmd ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal Structure of Human Haspin with an Isoquinoline ligand===
+
==See Also==
-
 
+
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[3fmd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMD OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Non-specific serine/threonine protein kinase]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra C]]
-
[[Category: Burgess-Brown, N.]]
+
[[Category: Burgess-Brown N]]
-
[[Category: Delft, F Von.]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M.]]
+
[[Category: Eswaran J]]
-
[[Category: Eswaran, J.]]
+
[[Category: Fedorov O]]
-
[[Category: Fedorov, O.]]
+
[[Category: Filippakopoulos P]]
-
[[Category: Filippakopoulos, P.]]
+
[[Category: Keates T]]
-
[[Category: Keates, T.]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S.]]
+
[[Category: Pike ACW]]
-
[[Category: Pike, A C.W.]]
+
[[Category: Weigelt J]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Von Delft F]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Cell cycle]]
+
-
[[Category: Chromatin regulator]]
+
-
[[Category: Germ cell associated 2]]
+
-
[[Category: Haploid germ cell specific nuclear protein kinase]]
+
-
[[Category: Haspin]]
+
-
[[Category: Kinase]]
+
-
[[Category: Magnesium]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Serine/threonine-protein kinase]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal Structure of Human Haspin with an Isoquinoline ligand

PDB ID 3fmd

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fmd"
Personal tools