3fgh

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[[Image:3fgh.png|left|200px]]
 
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{{STRUCTURE_3fgh| PDB=3fgh | SCENE= }}
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==Human mitochondrial transcription factor A box B==
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<StructureSection load='3fgh' size='340' side='right'caption='[[3fgh]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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===Human mitochondrial transcription factor A box B===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3fgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FGH FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19304746}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fgh OCA], [https://pdbe.org/3fgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fgh RCSB], [https://www.ebi.ac.uk/pdbsum/3fgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fgh ProSAT]</span></td></tr>
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[[3fgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FGH OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/TFAM_HUMAN TFAM_HUMAN] Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.<ref>PMID:1737790</ref> <ref>PMID:20410300</ref> <ref>PMID:19304746</ref> <ref>PMID:22037172</ref> <ref>PMID:22037171</ref>
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<ref group="xtra">PMID:019304746</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fg/3fgh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fgh ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Churchill, M E.A.]]
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[[Category: Large Structures]]
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[[Category: Gangelhoff, T A.]]
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[[Category: Churchill MEA]]
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[[Category: Mungalachetty, P.]]
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[[Category: Gangelhoff TA]]
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[[Category: Nix, J.]]
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[[Category: Mungalachetty P]]
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[[Category: Activator]]
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[[Category: Nix J]]
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[[Category: Dna-binding]]
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[[Category: Hmg domain]]
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[[Category: Mitochondrial transcription]]
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[[Category: Mitochondrion]]
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[[Category: Phosphoprotein]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transit peptide]]
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Current revision

Human mitochondrial transcription factor A box B

PDB ID 3fgh

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