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3f6m

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[[Image:3f6m.png|left|200px]]
 
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{{STRUCTURE_3f6m| PDB=3f6m | SCENE= }}
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==Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF from Yersinia pestis==
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<StructureSection load='3f6m' size='340' side='right'caption='[[3f6m]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
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===Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF from Yersinia pestis===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3f6m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F6M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.96&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[3f6m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F6M OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f6m OCA], [https://pdbe.org/3f6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f6m RCSB], [https://www.ebi.ac.uk/pdbsum/3f6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f6m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISPF_YERPE ISPF_YERPE] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/3f6m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f6m ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[MECDP synthase|MECDP synthase]]
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*[[MECDP synthase 3D structures|MECDP synthase 3D structures]]
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[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
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__TOC__
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[[Category: Yersinia pestis]]
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</StructureSection>
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[[Category: Anderson, W F.]]
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[[Category: Large Structures]]
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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[[Category: Yersinia pestis CO92]]
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[[Category: Joachimiak, A.]]
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[[Category: Anderson WF]]
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[[Category: Kim, Y.]]
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[[Category: Joachimiak A]]
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[[Category: Maltseva, N.]]
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[[Category: Kim Y]]
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[[Category: Stam, J.]]
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[[Category: Maltseva N]]
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[[Category: Alpha-beta structure]]
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[[Category: Stam J]]
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[[Category: Center for structural genomics of infectious disease]]
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[[Category: Csgid]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Lyase]]
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[[Category: Metal-binding]]
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[[Category: Structural genomics of infectious disease]]
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Current revision

Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF from Yersinia pestis

PDB ID 3f6m

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