3sb0

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[[Image:3sb0.png|left|200px]]
 
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{{STRUCTURE_3sb0| PDB=3sb0 | SCENE= }}
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==Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid inhibitor==
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<StructureSection load='3sb0' size='340' side='right'caption='[[3sb0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sb0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SB0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.199&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I93:4-(2-CHLORO-6-FLUORO-3-METHYLPHENYL)-2,4-DIOXOBUTANOIC+ACID'>I93</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sb0 OCA], [https://pdbe.org/3sb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sb0 RCSB], [https://www.ebi.ac.uk/pdbsum/3sb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sb0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MASZ_MYCTU MASZ_MYCTU] Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA (By similarity).[HAMAP-Rule:MF_00641]
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===Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid inhibitor===
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==See Also==
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*[[Malate synthase 3D structures|Malate synthase 3D structures]]
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{{ABSTRACT_PUBMED_23261599}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3sb0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SB0 OCA].
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[[Category: Malate synthase]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Krieger, I V.]]
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[[Category: Krieger IV]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sacchettini JC]]
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[[Category: Sun, Q.]]
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[[Category: Sun Q]]
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[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]]
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[[Category: Inhibitor complex]]
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[[Category: Malate synthase]]
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[[Category: Mycobacterium tuberculosis structural proteomics project]]
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[[Category: Structural genomic]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Xmtb]]
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Current revision

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid inhibitor

PDB ID 3sb0

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