4i1t
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the cap-snatching endonuclease from Pichinde virus== | |
| + | <StructureSection load='4i1t' size='340' side='right'caption='[[4i1t]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4i1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cali_mammarenavirus Cali mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1T FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1t OCA], [https://pdbe.org/4i1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1t RCSB], [https://www.ebi.ac.uk/pdbsum/4i1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q915A5_PIARV Q915A5_PIARV] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836] | ||
| - | + | ==See Also== | |
| - | + | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Cali mammarenavirus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bussetta C]] | ||
| + | [[Category: Choi KH]] | ||
Current revision
Crystal structure of the cap-snatching endonuclease from Pichinde virus
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