4j36
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)== | |
| + | <StructureSection load='4j36' size='340' side='right'caption='[[4j36]], [[Resolution|resolution]] 2.13Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4j36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J36 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1HR:(1S,2S)-2-(3,4-DICHLOROBENZOYL)CYCLOPROPANECARBOXYLIC+ACID'>1HR</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j36 OCA], [https://pdbe.org/4j36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j36 RCSB], [https://www.ebi.ac.uk/pdbsum/4j36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j36 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KMO_YEAST KMO_YEAST] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.<ref>PMID:12062417</ref> <ref>PMID:15806102</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Monooxygenase 3D structures|Monooxygenase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Amaral M]] | ||
| + | [[Category: Giorgini F]] | ||
| + | [[Category: Heyes DJ]] | ||
| + | [[Category: Lafite P]] | ||
| + | [[Category: Levy C]] | ||
| + | [[Category: Leys D]] | ||
| + | [[Category: Outeiro TF]] | ||
| + | [[Category: Scrutton NS]] | ||
Current revision
Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)
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