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4j74
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4j74 is ON HOLD Authors: JANSON, C., LUKACS, C., KAMMLOTT, U., GRAVES, B. Description: THE 1.2a CRYSTAL STRUCTURE OF HUMANIZED XENOPUS MDM2 WITH RO...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment== |
| + | <StructureSection load='4j74' size='340' side='right'caption='[[4j74]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4j74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J74 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I18:(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-METHYL-4,5-DIHYDRO-1H-IMIDAZOLE'>I18</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j74 OCA], [https://pdbe.org/4j74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j74 RCSB], [https://www.ebi.ac.uk/pdbsum/4j74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j74 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[MDM2 3D structures|MDM2 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Graves B]] | ||
| + | [[Category: Janson C]] | ||
| + | [[Category: Kammlott U]] | ||
| + | [[Category: Lukacs C]] | ||
Current revision
The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment
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