4j8c
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4j8c is ON HOLD Authors: Li, Z., Bracher, A. Description: Crystal structure of the dimerization domain of Hsc70-interacting protein) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the dimerization domain of Hsc70-interacting protein== | |
| - | + | <StructureSection load='4j8c' size='340' side='right'caption='[[4j8c]], [[Resolution|resolution]] 1.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4j8c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J8C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j8c OCA], [https://pdbe.org/4j8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j8c RCSB], [https://www.ebi.ac.uk/pdbsum/4j8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j8c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/F10A1_RAT F10A1_RAT] One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Bracher A]] | ||
| + | [[Category: Li Z]] | ||
Current revision
Crystal structure of the dimerization domain of Hsc70-interacting protein
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