4euk

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[[Image:4euk.jpg|left|200px]]
 
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{{STRUCTURE_4euk| PDB=4euk | SCENE= }}
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==Crystal structure==
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<StructureSection load='4euk' size='340' side='right'caption='[[4euk]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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===Crystal structure===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4euk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EUK FirstGlance]. <br>
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{{ABSTRACT_PUBMED_23132142}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4euk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4euk OCA], [https://pdbe.org/4euk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4euk RCSB], [https://www.ebi.ac.uk/pdbsum/4euk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4euk ProSAT]</span></td></tr>
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[[4euk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUK OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AHK5_ARATH AHK5_ARATH] Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. Negative regulator of the ETR1-dependent abscisic acid (ABA) and ethylene signaling pathway that inhibits the root elongation. Promotes stomatal closure. Regulates stomatal opening by integrating multiple signals via hydrogen peroxide H(2)O(2) homeostasis in guard cells in an ABA-independent manner. May contribute to basal defense mechanisms by closing stomata in the presence of bacterial pathogens. Regulates both hormone levels and ROS production in response to stress. Required for full immunity to bacterial pathogen and necrotrophic fungus.<ref>PMID:17202180</ref> <ref>PMID:18077346</ref> <ref>PMID:18560512</ref> <ref>PMID:22256998</ref> <ref>PMID:22827948</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Histidine kinase]]
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[[Category: Large Structures]]
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[[Category: Bauer, J.]]
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[[Category: Bauer J]]
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[[Category: Stehle, T.]]
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[[Category: Stehle T]]
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[[Category: Multistep phosphorelay]]
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[[Category: Phosphotransfer protein]]
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[[Category: Plant signalling]]
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[[Category: Response regulator]]
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[[Category: Sensor histidine kinase]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein]]
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[[Category: Transferase]]
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[[Category: Two-component system]]
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Crystal structure

PDB ID 4euk

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