2a72

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:11, 14 February 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2a72.gif|left|200px]]<br /><applet load="2a72" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2a72, resolution 2.00&Aring;" />
 
-
'''Structure of the regulator of G-protein signaling domain of RGS7'''<br />
 
-
==About this Structure==
+
==Structure of the regulator of G-protein signaling domain of RGS7==
-
2A72 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A72 OCA].
+
<StructureSection load='2a72' size='340' side='right'caption='[[2a72]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2a72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A72 FirstGlance]. <br>
-
[[Category: Arrowsmith, C.]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
[[Category: Debreczeni, J.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-
[[Category: Delft, F von.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a72 OCA], [https://pdbe.org/2a72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a72 RCSB], [https://www.ebi.ac.uk/pdbsum/2a72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a72 ProSAT]</span></td></tr>
-
[[Category: Doyle, D A.]]
+
</table>
-
[[Category: Edwards, A.]]
+
== Function ==
-
[[Category: Elkins, J M.]]
+
[https://www.uniprot.org/uniprot/RGS7_HUMAN RGS7_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity).
-
[[Category: Gileadi, O.]]
+
== Evolutionary Conservation ==
-
[[Category: Johansson, C.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Phillips, C.]]
+
Check<jmol>
-
[[Category: SGC, Structural Genomics Consortium.]]
+
<jmolCheckbox>
-
[[Category: Schoch, G A.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/2a72_consurf.spt"</scriptWhenChecked>
-
[[Category: Smee, C.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Sundstrom, M.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: CL]]
+
</jmolCheckbox>
-
[[Category: gtpase-activating proteins (gap)]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a72 ConSurf].
-
[[Category: human rgs7]]
+
<div style="clear:both"></div>
-
[[Category: regulator of g-protein signaling 7]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomics]]
+
-
[[Category: structural genomics consortium]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:24:21 2008''
+
==See Also==
 +
*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith C]]
 +
[[Category: Debreczeni J]]
 +
[[Category: Doyle DA]]
 +
[[Category: Edwards A]]
 +
[[Category: Elkins JM]]
 +
[[Category: Gileadi O]]
 +
[[Category: Johansson C]]
 +
[[Category: Phillips C]]
 +
[[Category: Schoch GA]]
 +
[[Category: Smee C]]
 +
[[Category: Sundstrom M]]
 +
[[Category: Von Delft F]]

Current revision

Structure of the regulator of G-protein signaling domain of RGS7

PDB ID 2a72

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2a72"
Personal tools