3ga0

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[[Image:3ga0.png|left|200px]]
 
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{{STRUCTURE_3ga0| PDB=3ga0 | SCENE= }}
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==CtBP1/BARS Gly172->Glu mutant structure: impairing NAD(H) binding and dimerization==
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<StructureSection load='3ga0' size='340' side='right'caption='[[3ga0]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ga0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GA0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ga0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga0 OCA], [https://pdbe.org/3ga0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ga0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ga0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ga0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTBP1_RAT CTBP1_RAT] Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Functions in brown adipose tissue (BAT) differentiation.<ref>PMID:10364211</ref> <ref>PMID:7624370</ref> <ref>PMID:12805226</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3ga0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ga0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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C-terminal binding proteins (CtBPs) are multi-functional proteins involved in nuclear transcriptional co-repression, Golgi membrane fission, and synaptic ribbon formation. Binding of NAD(H) to CtBPs promotes dimerization. CtBP dimers act as a scaffold for multimeric protein complex formation, thus bridging transcriptional repressors and their targets in the nucleus. Based on size-exclusion chromatography experiments and on the crystal structure of the NAD(H)-free G172E CtBP mutant, we show here that absence of NAD(H) induces flexibility/backbone conformational changes at the dimerization interface and at the CtBP interdomain region. The results presented shed first light on the correlation between NAD(H)-binding and functional CtBP dimerization.
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===CtBP1/BARS Gly172->Glu mutant structure: impairing NAD(H) binding and dimerization===
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CtBP1/BARS Gly172--&gt;Glu mutant structure: impairing NAD(H)-binding and dimerization.,Nardini M, Valente C, Ricagno S, Luini A, Corda D, Bolognesi M Biochem Biophys Res Commun. 2009 Mar 27;381(1):70-4. Epub 2009 Feb 10. PMID:19351597<ref>PMID:19351597</ref>
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{{ABSTRACT_PUBMED_19351597}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3ga0" style="background-color:#fffaf0;"></div>
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[[3ga0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA0 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019351597</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Corda, D.]]
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[[Category: Corda D]]
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[[Category: Luini, A.]]
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[[Category: Luini A]]
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[[Category: Nardini, M.]]
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[[Category: Nardini M]]
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[[Category: Ricagno, S.]]
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[[Category: Ricagno S]]
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[[Category: Valente, C.]]
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[[Category: Valente C]]
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[[Category: Acyl-coa]]
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[[Category: Acyltransferase]]
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[[Category: Adp-ribosylation]]
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[[Category: Brefeldin some]]
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[[Category: Golgi membrane]]
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[[Category: Nad]]
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[[Category: Nucleus]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphoprotein]]
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[[Category: Transcription co-repression]]
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Current revision

CtBP1/BARS Gly172->Glu mutant structure: impairing NAD(H) binding and dimerization

PDB ID 3ga0

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