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3g3z
From Proteopedia
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| - | [[Image:3g3z.png|left|200px]] | ||
| - | + | ==The structure of NMB1585, a MarR family regulator from Neisseria meningitidis== | |
| + | <StructureSection load='3g3z' size='340' side='right'caption='[[3g3z]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3g3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neimi Neimi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G3Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NMB1585 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 NEIMI])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3z OCA], [https://pdbe.org/3g3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g3z RCSB], [https://www.ebi.ac.uk/pdbsum/3g3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/3g3z_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g3z ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of the MarR-family transcription factor NMB1585 from Neisseria meningitidis has been solved using data extending to a resolution of 2.1 A. Overall, the dimeric structure resembles those of other MarR proteins, with each subunit comprising a winged helix-turn-helix (wHtH) domain connected to an alpha-helical dimerization domain. The spacing of the recognition helices of the wHtH domain indicates that NMB1585 is pre-configured for DNA binding, with a putative inducer pocket that is largely occluded by the side chains of two aromatic residues (Tyr29 and Trp53). NMB1585 was shown to bind to its own promoter region in a gel-shift assay, indicating that the protein acts as an auto-repressor. | ||
| - | + | The structure of NMB1585, a MarR-family regulator from Neisseria meningitidis.,Nichols CE, Sainsbury S, Ren J, Walter TS, Verma A, Stammers DK, Saunders NJ, Owens RJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt, 3):204-9. Epub 2009 Feb 26. PMID:19255465<ref>PMID:19255465</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3g3z" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Nichols, C E | + | [[Category: Neimi]] |
| - | [[Category: OPPF, Oxford Protein Production Facility | + | [[Category: Nichols, C E]] |
| - | [[Category: Owens, R J | + | [[Category: OPPF, Oxford Protein Production Facility]] |
| - | [[Category: Ren, J | + | [[Category: Owens, R J]] |
| - | [[Category: Sainsbury, S | + | [[Category: Ren, J]] |
| - | [[Category: Saunders, N J | + | [[Category: Sainsbury, S]] |
| - | [[Category: Stammers, D K | + | [[Category: Saunders, N J]] |
| - | [[Category: Verma, A | + | [[Category: Stammers, D K]] |
| - | [[Category: Walter, T S | + | [[Category: Verma, A]] |
| + | [[Category: Walter, T S]] | ||
[[Category: Marr]] | [[Category: Marr]] | ||
[[Category: Neisseria meningitidi]] | [[Category: Neisseria meningitidi]] | ||
Current revision
The structure of NMB1585, a MarR family regulator from Neisseria meningitidis
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Categories: Large Structures | Neimi | Nichols, C E | OPPF, Oxford Protein Production Facility | Owens, R J | Ren, J | Sainsbury, S | Saunders, N J | Stammers, D K | Verma, A | Walter, T S | Marr | Neisseria meningitidi | Oppf | Oxford protein production facility | Structural genomic | Transcription | Transcription factor
